Product Description
I was very excited to learn about this substance, PEA (Palmitoylethanolamide), and its promising effect on chronic pain for conditions such as arthritis, neuropathy, fibromyalgia, and more.
About this item
- Bioclinic Naturals PEA Palmitoylethanolamide 400 mg comes with 90 vegetarian capsules per bottle
- PEA or Palmitoylethanolamide is a natural fatty acid
- The active ingredient is micronized from safflower seeds to improve bioavailability
- Contains NO artificial colors, preservatives, sweetners, dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts nor GMOs
- Suitable for vegans and vegetarians
Bioclinic Naturals PEA Palmitoylethanolamide 400 mg 90 Vegetarian Capsules show a wide array of benefits. This product's active ingredient is micronized from safflower seeds to improve bioavailability and provides 400 mg PEA per capsule. This product contains NO artificial colors, preservatives, sweetners, dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts nor GMOs and is suitable for both vegetarians and vegans.
Suggested Use: Based on the dosing used indicated in studies I've read, I recommend 1200 mg/day in divided doses, so that would mean 1 capsule three times daily.
Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis
Abstract
Objective. To assess the efficacy and safety of palmitoylethanolamide (PEA), an endogenous fatty acid amide belonging to the N-acylethanolamines family, in reducing pain severity in patients with pain associated to different pathological conditions.
Methods. This was an observational study conducted on 610 patients who were unable to effectively control chronic pain with standard therapies. PEA (600 mg) was administered twice daily for 3 weeks followed by single daily dosing for 4 weeks, in addition to standard analgesic therapies or as single therapy. The primary outcome measure was the mean score pain severity evaluated by the numeric rating scale. Safety was also evaluated.
Results. PEA treatment significantly decreased the mean score pain intensity evaluated in all patients who completed the study. The PEA effect was independent of the pain associated pathological condition. PEA-induced decrease of pain intensity was present also in patients without concomitant analgesic therapy. Importantly, PEA showed no adverse effects.
Conclusions. In this study, PEA was effective and safe in the management of chronic pain in different pathological conditions.
Palmitoylethanolamide: A Natural Compound for Health Management
Abstract
All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management.